Samples – Multiple choice questions of basic virology (part II)

1.What is a virion?
a.Inactivated virus b. Infective virus
c.viral capsid d. Defective virus

2. Virions of …………. are in two groups of sense and antisense strand viruses.
a. Adeno virus b. Parvo virus c. Herpes virus d. Hepadna virus

3. 33oC is the optimum multiplication temperature for ……………. .
a. Retro virus b. Entero virus c. Influenza virus d. Paramyxo virus

4. Viral genome of………………….. is (+)ss RNA but it cannot be translated directly by ribosomes like mRNA.
a. Paramyxo virus b.Picorna virus c. Toga virus d. Retro virus

5.Which chemical substances can inactivate prions?
a.DNase b. RNase c. both a & b d.Not a & b

6. ……………. is an antiviral drug which inactivate reverse transcriptase?
a.Ribavirin b. Vidarabin c. Azidothymidin d. Gancyclovir

7. …………….. contains the non segmented genome.
a.Reo virus b. Myxo virus c. Arena virus d. Paramyxo virus

8. Infected cells to ………………… can show haemadsorption activity.
a. Adeno virus b. Polioma virus c.Influenza virus d. Parvo virus

9. Defective viruses dose not have …………….. .
a. One or several genes necessary for replication
b. Some nucleoproteins
c. Some parts of envelope
d. Some parts of capsid

10. Viroids …………………………………… .
a. need helper viruses b. contain circular dsDNA
c. don’t have DNA & RNA d. contain circular ssRNA

11. Amantidine hydrochloride drug inhibits ……………….. .
a. RNA synthesis b. Uncoating c. DNA synthesis d. Attachment

12. All the following items show interferon activity, EXCEPT.
a. Endonuclease activity b. Protein kinase
c. Activation of phosphodiesterase d. Protein cleavage

13. Macroscopic lesions on chorioallanthoic membrane of embryonated egg are produced by …… .
a. Influenza virus b. HSV-I c. Adeno virus d. Polio virus

14. (-)ssRNA viruses use ……………….. during genome replication.
a. reverse transcriptase b. RNA-dependent RNA polymerase
c. Thymidin kinase d. Neuraminidase

15.Interferons inhibit ……………………. .
a. viral uncoating
b.viral lysis & release c. viral mRNA translation
d. Viral adsorption to host cells

16. What is the common phenomenon in all viral infections?
a.DNA replication b. mRNA synthesis
c. Glycoprotein synthesis d. RNA dependent-DNA synthesis

17. Between ……………… is the Eclipse period.
a. Assemly & Release b. Adsorption & Assembly
c. Release & Assembly d. Adsorption & uncoating

18. Interference can be happened during the usage of ………………….. .
a. killed vaccines b. Attenuated vaccines c. recombinant vaccines d. vaccines containing viral subunits

19. Differentiation of enveloped and non enveloped viruses are related to the presence or absence of …………………….. .
a. nucleic acid b. lipids c. proteins d. enzymes

20. ……………… has the helical symmetry.
a. Adeno virus b. Influenza virus c. Herpes virus d. Parvo virus

21. Virion of …………………………. has reverse transcriptase.
a. HBV b. Rabies c. HCV d. CMV

22. Integrase is a necessary enzyme for ……………….. .
a. HAV b. HIV c. HCV d. Flavi virus

23. Nucleic acid of ……………….. can be used as a gene vector.
a. HBV b. Vaccina virus c. Influenza virus d. Rubbella virus

24. Some family members of ……………… for their replication need Adeno virus.
a. Parvoviridae b. Papiloma viridae c. Herpes viridae d. Pox viridae

25. What is the primary target of ultraviolet radiation on a virion?
a. capsid b. genome c. matrix d. envelope

With best wishes-FRZ

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